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2008 1
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2011 2
2013 1
2014 1
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2020 6
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2022 2
2023 5
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35 results

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Page 1
Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.
Li W, Lou X, Zha Y, Qin Y, Zha J, Hong L, Xie Z, Yang S, Wang C, An J, Zhang Z, Qiao S. Li W, et al. Elife. 2023 Apr 3;12:e80479. doi: 10.7554/eLife.80479. Elife. 2023. PMID: 37010266 Free PMC article.
Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy. ...Finally, we validated the role of the Itgb1 hub gene-mediated intercellular communication drivers of diabetic myocardial fibrosis in Hrc(hi) fibroblasts, and confirmed …
Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy. ...Finally, we validated the role of the I …
Knockdown of lncRNA MALAT1 attenuates renal interstitial fibrosis through miR-124-3p/ITGB1 axis.
Xia W, Chen X, Zhu Z, Chen H, Li B, Wang K, Huang L, Liu Z, Chen Z. Xia W, et al. Sci Rep. 2023 Oct 23;13(1):18076. doi: 10.1038/s41598-023-45188-y. Sci Rep. 2023. PMID: 37872392 Free PMC article.
Moreover, knockdown of lncRNA MALAT1 remarkably downregulated the proteins level of fibrosis-related markers, ITGB1, and upregulated the expression of epithelial marker E-cadherin. Consistently, mechanistic studies showed that miR-124-3p can directly binds to lncRNA …
Moreover, knockdown of lncRNA MALAT1 remarkably downregulated the proteins level of fibrosis-related markers, ITGB1, and upreg …
Rosavin Ameliorates Hepatic Inflammation and Fibrosis in the NASH Rat Model via Targeting Hepatic Cell Death.
Albadawy R, Hasanin AH, Agwa SHA, Hamady S, Aboul-Ela YM, Raafat MH, Kamar SS, Othman M, Yahia YA, Matboli M. Albadawy R, et al. Int J Mol Sci. 2022 Sep 5;23(17):10148. doi: 10.3390/ijms231710148. Int J Mol Sci. 2022. PMID: 36077546 Free PMC article.
The data revealed that rosavin had the ability to modulate the expression of the hepatic cell death-related RNA panel through the upregulation of both (HSPD1/TNF/MMP14/ITGB1) mRNAs and their epigenetic regulators (miRNA-6881-5P and lnc-SPARCL1-1:2). ...The produced effect …
The data revealed that rosavin had the ability to modulate the expression of the hepatic cell death-related RNA panel through the upregulati …
Extracellular Matrix Stiffness Regulates Microvascular Stability by Controlling Endothelial Paracrine Signaling to Determine Pericyte Fate.
Yu Y, Leng Y, Song X, Mu J, Ma L, Yin L, Zheng Y, Lu Y, Li Y, Qiu X, Zhu H, Li J, Wang D. Yu Y, et al. Arterioscler Thromb Vasc Biol. 2023 Oct;43(10):1887-1899. doi: 10.1161/ATVBAHA.123.319119. Epub 2023 Aug 31. Arterioscler Thromb Vasc Biol. 2023. PMID: 37650330
Soft ECM promoted microvascular regeneration and inhibited fibrosis in bone graft transplantation in vivo. As integrins are the major mechanosensor, we performed RT-qPCR screening of integrin family members and found Itgb1 (integrin beta1) was the major subunit down …
Soft ECM promoted microvascular regeneration and inhibited fibrosis in bone graft transplantation in vivo. As integrins are the major …
FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro.
Yeung V, Sriram S, Tran JA, Guo X, Hutcheon AEK, Zieske JD, Karamichos D, Ciolino JB. Yeung V, et al. Biomolecules. 2021 Nov 12;11(11):1682. doi: 10.3390/biom11111682. Biomolecules. 2021. PMID: 34827680 Free PMC article.
Corneal fibrosis (or scarring) occurs in response to ocular trauma or infection, and by reducing corneal transparency, it can lead to visual impairment and blindness. ...Results show that hCF 3D constructs treated with TGF-beta1 or TGF-beta3 impart distinct effects on gene …
Corneal fibrosis (or scarring) occurs in response to ocular trauma or infection, and by reducing corneal transparency, it can lead to …
The biomarkers associated with epithelial-mesenchymal transition in human keloids.
Qiu ZK, Yang E, Yu NZ, Zhang MZ, Zhang WC, Si LB, Wang XJ. Qiu ZK, et al. Burns. 2024 Mar;50(2):474-487. doi: 10.1016/j.burns.2023.09.009. Epub 2023 Sep 26. Burns. 2024. PMID: 37980270
In the Cytohubba plugin, 10 hub genes were explored, including FN1, EGF, SOX9, CDH2, PROM1, EPCAM, KRT19, ITGB1, CD24, and KRT18. These genes were then enriched for the focal adhesion pathway. ...Based on the ERDEGs and 10 hub genes mentioned above, ribavirin demonstrated …
In the Cytohubba plugin, 10 hub genes were explored, including FN1, EGF, SOX9, CDH2, PROM1, EPCAM, KRT19, ITGB1, CD24, and KRT18. The …
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis.
Ruiz-Ojeda FJ, Wang J, Bäcker T, Krueger M, Zamani S, Rosowski S, Gruber T, Onogi Y, Feuchtinger A, Schulz TJ, Fässler R, Müller TD, García-Cáceres C, Meier M, Blüher M, Ussar S. Ruiz-Ojeda FJ, et al. Mol Metab. 2021 Mar;45:101147. doi: 10.1016/j.molmet.2020.101147. Epub 2021 Jan 7. Mol Metab. 2021. PMID: 33359386 Free PMC article.
OBJECTIVE: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation. ...METHODS: We characterized integrin activity in adipose tissue and its consequences on …
OBJECTIVE: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a k …
Type V collagen induced tolerance suppresses collagen deposition, TGF-beta and associated transcripts in pulmonary fibrosis.
Vittal R, Mickler EA, Fisher AJ, Zhang C, Rothhaar K, Gu H, Brown KM, Emtiazjoo A, Lott JM, Frye SB, Smith GN, Sandusky GE, Cummings OW, Wilkes DS. Vittal R, et al. PLoS One. 2013 Oct 21;8(10):e76451. doi: 10.1371/journal.pone.0076451. eCollection 2013. PLoS One. 2013. PMID: 24204629 Free PMC article.
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and matrix deposition. ...Compared to controls, nebulized col(V)-induced tolerance abrogated antigen-specific proliferation in mediastinal lymphocytes …
RATIONALE: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and matrix …
Clinical Significance of HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 RNA Panel in NAFLD/NASH Diagnosis: Egyptian Pilot Study.
Albadawy R, Agwa SHA, Khairy E, Saad M, El Touchy N, Othman M, Matboli M. Albadawy R, et al. Biomedicines. 2021 Sep 17;9(9):1248. doi: 10.3390/biomedicines9091248. Biomedicines. 2021. PMID: 34572434 Free PMC article.
METHODS: Bioinformatics analysis was done, with retrieval of the HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 RNA panel based on the relation to the NLR-signaling pathway. ...CONCLUSION: This pilot study concluded that HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 …
METHODS: Bioinformatics analysis was done, with retrieval of the HSPD1/MMP14/ITGB1/miR-6881-5P/Lnc-SPARCL1-1:2 RNA panel based on the …
Small molecule proteomics quantifies differences between normal and fibrotic pulmonary extracellular matrices.
Wan XL, Zhou ZL, Wang P, Zhou XM, Xie MY, Mei J, Weng J, Xi HT, Chen C, Wang ZY, Wang ZB. Wan XL, et al. Chin Med J (Engl). 2020 May 20;133(10):1192-1202. doi: 10.1097/CM9.0000000000000754. Chin Med J (Engl). 2020. PMID: 32433051 Free PMC article.
In addition, the interactions of extracellular DESMPs suggested that the extracellular proteins Alb, Itgb1, Apoa1, P4hb, and Fgg in ECM could be potentially used as biomarker candidates for pulmonary fibrosis. These results provided useful information and new insigh …
In addition, the interactions of extracellular DESMPs suggested that the extracellular proteins Alb, Itgb1, Apoa1, P4hb, and Fgg in E …
35 results